Clinical trial manufacture

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In general the following technologies can be applied for CTS:

  • Blending
  • Fluidized bed granulation
  • Wet granulation (tray or vacuum drying)
  • Compaction
  • Encapsulation (hard gelatine or HPMC capsules)
  • Coating of particles and pellets
  • Film-coating (rotating pan and fluidized bed)
  • Pelletizing by extrusion and spheronization
  • Melt extrusion
  • Hot melt extrusion
  • Nanomilling

Ranges from 250 g to 20 kg can be applied for most of the mentioned technologies.